Canadian Forest Service Publications
Antifungal antibiotics from Pisolithus tinctorius. 1991. Tsantrizos, Y.S.; Kope, H.H.; Fortin, J.A.; Ogilvie, K.K. Phytochemistry 30(4): 1113-1118.
Issued by: Pacific Forestry Centre
Catalog ID: 3253
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The antibiotic compounds p-hydroxybenzoylformic acid [2-(4'-hydroxyphenyl)-2-oxoethanoic acid, pisolithin A] and (R)-(–)-p-hydroxymandelic acid [(R)-(–)-2-(4'-hydroxyphenyl)-2-hydroxyethanoic acid, pisolithin B] were isolated from the growth culture of Pisolithus tinctorius. Both of these metabolites, and a few structurally related compounds, were shown to inhibit spore germination and cause hyphal lysis to a significant number of phytopathogenic and dermatogenic fungi. Hence, it was concluded that P. tinctorius aids its host plants by providing protection against disease-causing microorganisms.