Canadian Forest Service Publications

Genomic selection accuracies within and between environments and small breeding groups in white spruce. 2014. Beaulieu, J.; Doerksen, T.K.; MacKay, J.; Rainville, A.; Bousquet, J. 2014. BMC Genomics 15:1048.

Year: 2014

Available from: Laurentian Forestry Centre

Catalog ID: 35830

Language: English

CFS Availability: PDF (request by e-mail)

Abstract

Background: Genomic selection (GS) may improve selection response over conventional pedigree-based selection if markers capture more detailed information than pedigrees in recently domesticated tree species and/or make it more cost effective. Genomic prediction accuracies using 1748 trees and 6932 SNPs representative of as many distinct gene loci were determined for growth and wood traits in white spruce, within and between environments and breeding groups (BG), each with an effective size of Ne ≈ 20. Marker subsets were also tested.

Results: Model fits and/or cross-validation (CV) prediction accuracies for ridge regression (RR) and the least absolute shrinkage and selection operator models approached those of pedigree-based models. With strong relatedness between CV sets, prediction accuracies for RR within environment and BG were high for wood (r = 0.71–0.79) and moderately high for growth (r = 0.52–0.69) traits, in line with trends in heritabilities. For both classes of traits, these accuracies achieved between 83% and 92% of those obtained with phenotypes and pedigree information. Prediction into untested environments remained moderately high for wood (r ≥ 0.61) but dropped significantly for growth (r ≥ 0.24) traits, emphasizing the need to phenotype in all test environments and model genotype-byenvironment interactions for growth traits. Removing relatedness between CV sets sharply decreased prediction accuracies for all traits and subpopulations, falling near zero between BGs with no known shared ancestry. For marker subsets, similar patterns were observed but with lower prediction accuracies.

Conclusions: Given the need for high relatedness between CV sets to obtain good prediction accuracies, we recommend to build GS models for prediction within the same breeding population only. Breeding groups could be merged to build genomic prediction models as long as the total effective population size does not exceed 50 individuals in order to obtain high prediction accuracy such as that obtained in the present study. A number of markers limited to a few hundred would not negatively impact prediction accuracies, but these could decrease more rapidly over generations. The most promising short-term approach for genomic selection would likely be the selection of superior individuals within large full-sib families vegetatively propagated to implement multiclonal forestry.

Plain Language Summary

In this study, the researchers examined ways to obtain the best possible accuracy for predicting wood quality and growth characteristics in white spruce using genetic data. They recommend using genomic selection models to select trees within the same breeding group for which the models were constructed; indeed, these models cannot be applied universally.

Genomic selection consists in predicting the genetic value of an individual based on its genetic profile, which is obtained using a very large number of markers. It is attracting more and more interest from managers responsible for tree breeding programs. In essence, genomic selection allows for the earlier prediction of trees’ genetic potential than traditional methods by eliminating the testing period, which can be as long as thirty years. Consequently, it can facilitate quicker access to a greater quality wood supply.

Funding programs

  • Forest Innovation Program
Genomic selection accuracies within and between environments and small breeding groups in white spruce.
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